Prevalence and factors associated with


Original article

Prevalence and factors associated with dyslipidemia after liver transplantation

Prevalence and factors associated with dyslipidemia after liver transplantation Hélem de Sena Ribeiro¹*, Lucilene Rezende Anastácio2, Lívia Garcia Ferreira3, Érika Barbosa Lagares4, Agnaldo Soares Lima5, Maria Isabel Toulson Davisson Correia5 1

Postgraduate Program in Food Science, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.


Postgraduate Program in Adult Health, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.


Postgraduate Program in Sciences applied to Surgery and Ophthalmology, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.


Nutritionist, Graduate of the University of Itaúna, Itaúna, MG, Brazil.


Alfa Institute of Gastroenterology, Hospital das Clínicas, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.


Study conducted at the Alfa Institute of Gastroenterology, Faculty of Medicine, Hospital das Clínicas, Belo Horizonte, MG, Brazil Article received: 9/30/2013 Accepted for publication: 1/13/2014 *Correspondence: Address: Avenida Alfredo Balena 110, Sala 208 ZIP Code: 31270-901 Belo Horizonte, Minas Gerais, MG - Brazil Phone: +55 31 3409 4186 [email protected]

Objective: to determine the prevalence of abnormal total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL) and triglycerides in patients undergoing liver transplantation (LTx) and to identify predictors of these disorders. Methods: cross-sectional study to assess the prevalence of dyslipidemia in patients undergoing LTx. Demographic, socioeconomic, clinical, anthropometric and dietetic data were collected to determine the association with dyslipidemia using univariate and multivariate statistical analysis. Results: 136 patients were evaluated, 68.1% of which had at least one type of dyslipidemia. The triglyceride level was high in 32.4% of cases, with low HDL in 49.3% of patients and high LDL levels in only 8.8%. High total cholesterol was observed in 16.2% of the study population and was associated with the recommendation for transplantation due to ethanolic cirrhosis (OR = 2.7) and a greater number of hours slept per night (OR = 1.5). Conclusion: many patients presented dyslipidemia after transplantation, demonstrating the need for interventions in relation to modifiable factors associated with dyslipidemias that can mitigate or prevent these disorders.

Conflict of interest: none

Uniterms: dyslipidemia, lipoprotein, prevalence, liver transplantation.

Introduction The most important risk factors for atherosclerosis include dyslipidemias, which represent an increase or decrease in plasma lipoproteins involved directly and indirectly in the atherothrombotic process.1 Many studies have described the high prevalence and incidence of this disorder in patients submitted to liver transplantation.2-6 Furthermore, other cardiovascular risk factors, such as hypertension, obesity and diabetes have been commonly reported after liver transplants.3, 5, 7 Therefore, patients submitted to this procedure have an increased risk of developing cardiovascular diseases – which have already been indicated as the third most common cause of death in this population by certain authors.8 Rev Assoc Med Bras 2014; 60(4):365-372

Changes in the lipid profile of patients submitted to transplants have been related to immunosuppressive drug treatment. Some authors have shown a greater increase in total cholesterol and triglycerides in patients submitted to long term immunosuppressive therapy with cyclosporine.2-4,9 Changing immunosuppressive treatment with ciclosporine for tacrolimus has also been related to a reduction in the levels of triglycerides and cholesterol in this population.9 There are also authors that attribute changes in the lipid profile to the use of prednisone, regardless of treatment with ciclosporine or tacrolimus.10 Immunosuppressive therapy with the use of sirolimus has also been strongly related to hyperlipidemia in pa-


Ribeiro HS et al.

tients submitted to kidney transplants.11-12 However, in patients submitted to liver transplants, this type of immunosuppression does not appear to cause significant alterations in plasma lipoproteins in comparison with other treatments.13 unless this medication is associated with cyclosporine.14 Although immunosuppressive medication has been widely studied as a possible cause of post-liver transplant dyslipidemias, few other risk factors have been studied. At present, nothing is known about the prevalence of dyslipidemias in the Brazilian population submitted to liver transplantation. The objective of this study was to determine the prevalence of abnormalities in total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL) and triglycerides in patients submitted to liver transplants, as well as identifying predictive factors for these disorders.

Methods This was a cross-sectional study evaluating the prevalence of dyslipidemia and associated factors in patients undergoing liver transplantation monitored at the transplant outpatient clinic at the Alfa Institute of Gastroenterology, Hospital das Clínicas, Federal University of Minas Gerais (Belo Horizonte – MG, Brazil). The study included patients who underwent transplantation, aged over 18 years, who had regular follow-ups at the clinic. Pregnant women, patients with ascites and/ or patients with less than one year since transplantation were excluded. The study was approved by the Ethics Committee at the Federal University of Minas Gerais under report no. ETIC 44/08. Patients were approached and asked about their interest in participating in the study while waiting for their medical consultation at the outpatient clinic. After signing an informed consent form, a questionnaire was applied with respect to demographic, socioeconomic, lifestyle, clinical, anthropometric and dietary data. Subsequently, after a 12 hour fast, patients underwent biochemical exams for measurement of plasma lipoproteins, along with the routine biochemical exams at the clinic. The cutoff points used for classification of dyslipidemias were those proposed by the III Brazilian Guidelines on Dyslipidemia (2001):15 borderline (150 – 200 mg/dL) and high triglycerides (≥ 200 mg/dL); grouped into increased triglycerides (≥ 150 mg/dL), low HDL (HDL ≤ 40mg/dL for men and ≤ 50

mg/dL for women), borderline (130 – 159 mg/dL) and high LDL (³160 mg/dL), which were grouped into increased LDL (≥ 130 mg/dL ), borderline (200 – 239 mg/ dL) and high cholesterol (≥ 240 mg/dL), grouped into increased total cholesterol levels (≥ 200 mg/dL). This classification served as the basis for determining the prevalence of dyslipidemia and the investigation into predictors. The data was collected directly from the medical records and with the aid of the questionnaire elaborated covering the demographic and socioeconomic variables as well as data on lifestyle, clinical and anthropometric details, past medical history and dietary intake. The patients were also questioned about their daily physical activities, which were then transformed into corresponding activity factors. 16 The daily activities transformed into factors were multiplied by the respective time spent and the results were added and divided over 24 hours. This value was categorized according to the daily level of physical activity carried out (<1.3: sedentary; 1.3-1.5: slightly active; 1.5-1.8: active; > 1.9: very active).17 The clinical data included indication for transplantation, time of use and accumulated dose of corticoids after transplantation, use of tacrolimus and cyclosporine, glucose levels, systolic and diastolic blood pressure, hypertension prior to transplantation and at the time of the interview, diabetes mellitus before transplantation and excess weight and obesity prior to liver disease (using the habitual weight informed by the patient during the inter view), family histor y of hypertension, diabetes mellitus and excess weight. The anthropometric data was constituted by weight, height, Body Mass Index (BMI), waist circumference (WC), hip circumference (HC) and the waist to hip ratio (WHR). According to the BMI (weight (kg) / height (m2) the patients were classified as being overweight (BMI ≥ 25 kg/m 2) or obese (BMI ≥ 30 kg/ m 2).18 The waist circumference measurement (measured two fingers above the navel) was considered as indicative of abdominal obesity according to the definitions of the World Health Organization (≥ 88 cm for women and ≥ 102 cm for men)18 and by the International Diabetes Federation (IDF) (≥ 80 cm and 90 cm, respectively).19 The dietetic data was obtained using habitual dietary history method. Food intake was evaluated in terms of calories, carbohydrates, proteins, fats (total, saturated, monounsaturated, polyunsaturated fats and

366Rev Assoc Med Bras 2014; 60(4):365-372

Prevalence and factors associated with dyslipidemia after liver transplantation

cholesterol), total fiber, vitamin A, C, D, E, thiamine, riboflavin, niacin, pantothenic acid, vitamin B 6, folic acid, vitamin B12, calcium, iron, magnesium, sodium, potassium and zinc with the aid of Microsoft Excel (Microsoft Corp, Redmond, WA) and the Food Composition Table: Support for Nutritional Decision. 20 The household measurements of food reported in the habitual dietary history were converted into grams with the help of the Food Intake Evaluation Table in Household Measures.21 The statistical analyses were conducted using the program Statistical Package for the Social Sciences (SPSS) for Windows (version 17.0), adopting an equal to 5% for statistical significance. The variables were presented in the form of means and standard deviations. However, variables with a non-normal distribution were presented in the form of median, minimum and maximum (Kolmogorov-Smirnov test). Factors associated with the

presence of dyslipidemia were tested through univariate and multivariate analyses. The statistical tests used in the univariate analysis were the Chi-squared test, Fisher’s exact test, Student’s t-test and Mann-Whitney U test. Variables with p < 0.2 in the univariate analysis were included in the multiple logistic regression model. The model was then adjusted according to the backward stepwise method. The Hosmer–Lemeshow test was used to check the adjustment of the model (p > 0.05). A multiple linear regression test was also used to identify factors associated with dyslipidemia.

Results 136 patients were evaluated with an average age of 52.2 ± 13 years, being 61% (n = 83) male. The average time since transplantation was approximately 4 ± 3 years. The general characteristics of the patients are described in Table 1.

Table 1  Demographic, socioeconomic, lifestyle and clinical data of the patients submitted to liver transplantation, Belo Horizonte-MG, 2013 Categorical variables



Numerical variables

Mean /

± Standard


deviation / Minimummaximum

Marital status - married



Per capita income (BR$)


83 – 6,000




Hours of sleep (per day)






Physical activity factor (MET/24)



Former smokers



Glucose (mg/dL)


61 – 346

Use of tacrolimus



Total cholesterol (mg/dL)



Use of cyclosporine



LDL (mg/dL)



Hypertension before transplantation



HDL (mg/dL)


18 – 162

Current hypertension



Triglycerides (mg/dL)


28 – 659

Diabetes mellitus before transplantation



Systolic blood pressure (mmHg)


90 – 180

Current diabetes mellitus



Diastolic blood pressure (mmHg)


50 – 110

Time using prednisone (months)


1.5 – 140

Indicated for transplantation VHC cirrhosis



Accumulated prednisone dose (g)


0.5 – 39.4

Ethanolic cirrhosis



BMI before liver disease 



Autoimmune hepatitis



Current BMI



Cryptogenic cirrhosis



Waist circumference



Cirrhosis and hepatocellular carcinoma



Hip circumference



Primary biliary cirrhosis



Waist–hip ratio



Secondary biliary cirrhosis




Rev Assoc Med Bras 2014; 60(4):365-372


Ribeiro HS et al.

A family history of hypertension, diabetes mellitus and excess weight was found in 73.7 % (n = 98), 48.5 % (n = 65) and 59 % (n = 79) of the patients assessed, respectively. A personal history of being overweight prior to liver disease was observed in 46.3 % (n = 63) of the patients and obesity in 16.2 % (n = 22). At the time of evaluation, the prevalence of excess weight was 59.6 % (n = 81) and obesity 20.6 % (n = 28). The quantification of dietetic intake of the patients evaluated is described in Table 2. The presence of at least one type of dyslipidemia was observed in 68.1% (n = 93) of the patients sub-

mitted to liver transplantation. The most frequent type of dyslipidemia was low HDL (49.3%; n = 67) and the least frequent was increased LDL (8.8%; n = 12), with 5.9% (n = 8) borderline and 2.9% (n=4) high levels. Total cholesterol was found to be increased in 16.2% (n = 22) of the patients, with 11% (n=15) borderline and 5.2% (n = 7) high levels. The triglyceride levels were increased in 32.4% (n = 44), with 15.4% (n = 21) showing borderline and 16.9% (n = 23) high levels. The predictive factors of these disorders are contained in Table 3.

Table 2  Dietetic consumption of patients submitted to liver transplantation, Belo Horizonte-MG, 2013 Nutrient







Kilocalories (kcal)




Carbohydrates (g)



Proteins (g)


Lipids (g)








Vitamin B12 (mcg)





Folic acid (mcg)






Calcium (mg)







Iron (mg)




Polyunsaturated lipids (g)




Magnesium (mg)




Monounsaturated lipids (g)




Potassium (mg)




Saturated lipids (g)




Sodium (mg)




Carbohydrates %




Zinc (mg)




Proteins %




Per group

Lipids %




Breads, cereals, tubers (g)




Polyunsaturated lipids %




Wholegrain cereals (g)




Monounsaturated lipids %




Greenery (g)




Saturated lipids %




Fruits (g)




Cholesterol (mg)




Vegetables (g)




Total fibers (g)




Meat (g)




Vitamin A (RE)




Sugar-sweetened beverages (g) 200



Vitamin C (mg)




Sweets (g)




Vitamin D (mcg)




Fats (g)




Vitamin E (mg)




Vitamin B1 (mg)




Milk (mL)




Vitamin B2 (mg)




Whole milk (mL)




Niacin (mg)




Skim milk (mL)




Vitamin B5 (mg)




Yogurt (mL)




Vitamin B6 (mg)




Cheese (g)





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Prevalence and factors associated with dyslipidemia after liver transplantation

Table 3  Independent risk factors associated with dyslipidemias after liver transplantation evaluated using multiple logistic regression, Belo Horizonte-MG, 2013 Associated independent factors



p Value

High TG Older age (years)


1.03 - 1.01


Indicated due to cryptogenic cirrhosis


1.00 - 1.06


Higher consumption of whole milk (mL)


1.00 - 1.004


Hosmer-Lemeshow test








Waist circumference > 88/102 cm


1.47 - 7.05


Triglycerides ≥ 150 mg/dL


0.99 - 1.01


Lower vegetable intake (g)


1.001 – 1.002


Hosmer-Lemeshow test




High LDL Higher folic acid intake (mg)


1.007 - 1.035


Lower potassium intake (mg)


1.01 - 1.001


Higher fruit intake (g)


1.001 - 1.011


Higher meat intake (g)


1.002 - 1.023




1.26 – 219.68


Presence of diabetes prior to transplantation


1.16 - 95.19


Hosmer-Lemeshow test




More hours of sleep per night


1.02 - 2.07


Indicated due to ethanolic cirrhosis


0.99 - 7.11


Hosmer-Lemeshow test




High TC

Discussion This study confirms that dyslipidemias are frequently seen in the population undergoing liver transplantation, given that 68.1% of the patients evaluated presented at least one of these disorders. This is a similar result to those already described in the international literature for this specific population, which indicated the prevalence of dyslipidemias between 66% and 85% of individuals.2, 22-24 However, the difficulty in comparing the prevalence should be reiterated, due to the different cutoff points used in different studies as well as the specific time in which the patient was evaluated after the transplant. In Brazil, few studies have been conducted to determine the prevalence of dyslipidemias in the general population and no population undergoing liver transplantation. The majority of these studies was conducted with restricted and limited groups and did not describe the entire lipid profile. We noted that the dyslipidemia prevalence values found in this study are generally higher than those described in the general population. The prevalence of increased triglycerides has already been indicated at 17.1 to 29.5% 2525-26,26 in the general Brazilian poRev Assoc Med Bras 2014; 60(4):365-372

pulation, and reduced HDL from 10.7 to 18.3%.25,26 On the other hand, the prevalence of increased total cholesterol and LDL are described in a greater percentage of the Brazilian population than that found in this study, from 21.6 to 40%27 and 3.5 to 31.1%,25-26 respectively. The prevalence of high triglycerides has already been reported as between 45 and 49.7% in the population submitted to liver transplantation,2, 4-5 which is higher than that found in this study (32.4%). Older age, an indication for cryptogenic cirrhosis and higher intake of whole milk were independently associated with the presence of increased triglycerides. In 2007, Alexander and colleagues showed an increase in triglyceride levels with increasing age, although the increase was found to be nonlinear, with some decline from 50 years of age. The dyslipidemia characterized by high triglyceride levels and often accompanied by low HDL levels is commonly found in patients with non-alcoholic fatty liver disease.28 A higher intake of whole milk was also associated with high triglycerides, which can probably be associated with the higher intake of total and saturated fats, which directly interfere with


Ribeiro HS et al.

lipid metabolism.1 However, it should be emphasized that neither the total fat intake or saturated fat intake in the habitual dietary history were associated with higher levels of triglycerides. The prevalence of low HDL was 49.3 %, in agreement with the values found in the literature, in which approximately half the population undergoing liver transplantation has low levels of this lipoprotein.3, 5, 23 Predictive factors for this finding in the study were abdominal obesity, high triglycerides, and low intake of vegetables. The inverse association between the consumption of vegetables, especially greens, and dyslipidemia has been well reported in the literature. This is attributed to the increased fiber content, antioxidant phytochemicals as well as the low glycemic index of such foods.30-31 High waist circumference is also indicated in the general population as a predictor of low HDL levels and consequent increased cardiovascular risk.32 Abdominal obesity is detrimental because the intra-abdominal fat is more likely to be subject to lipolysis, expressing an increased number of glucocorticoid receptors and more sensitive to catecholamines.33 Lipolysis generates more free fatty acids in the bloodstream, which will be released in large quantities into the hepatic portal circulation, promoting resistance in the tissue to the action of insulin, both in the liver and peripheral tissues.34 Insulin resistance will lead to hyperinsulinemia, which increases the flow of fatty acids in the liver, contributing to increased hepatic fat. Furthermore, increased synthesis of very low density lipoprotein (VLDL) increases triglyceride in the blood stream.35 Increased circulating triglycerides modify the composition and metabolism of HDL, reducing the cholesterol content of increasing triglycerides, which promotes increased clearance in the circulation.36 The prevalence of high LDL is rarely reported in the literature, both in the general population and those undergoing liver transplantation. In this study, increased potassium intake was a protective factor for high LDL. This micronutrient is present in vegetables (fruits, greens and legumes), which emphasizes the importance of increasing the intake of foods from this group.37 On the other hand, a higher intake of folic acid and fruits remained as a predictive factor for increased LDL values in the model. Although a higher intake of fruits and folic acid may protect individuals from increased plasma LDL and VLDL levels,31 in this study the contrary association observed may be due to changes in the lifestyles of patients with high LDL values. Furthermore, the absence of paid professional activity was associated with high LDL values. Patients with

liver failure often stop working or retire while they are seriously ill or on waiting lists for liver transplantation. However, even after transplantation, most of them usually do not return to work38 and/or remain sedentary, as low levels of physical activity are the norm among these individuals.39 It is known that moderate and constant physical exercise leads to decreased plasma concentration of LDL, by improving the control of oxidative stress in an acute manner, in addition to being inversely related to the atherogenic process.40 Despite this finding, no relationship between the level of physical activity and dyslipidemia was found in this study. This was probably due to the limitations of calculating the level of daily physical activity. Increased LDL levels were also associated with the presence of diabetes mellitus prior to transplantation. This can be attributed to the effects of hyperinsulinemia, since insulin resistance promotes an increased flow of free fatty acid and increases the number of VLDL particles and triglyceride plasma levels, promoting decreased levels of HDL and an increased concentration of LDL.41-42 The prevalence of increased cholesterol reported in the literature varies from 19 to 26% 2, 22, 24, higher levels than those found in our study (16.2%). A lower number of hours slept per night, especially less than seven, have been associated with high levels of total cholesterol and lower HDL.43 Sleep deprivation can increase the risk of hypercholesterolemia due to several factors. These include reports of increased appetite and increased dietary intake of saturated fats, decreased motivation to engage in regular physical activity, as well as promoting stress and increased levels of catecholamines.43 The identification of this variable as a predictor of increased total cholesterol levels in liver graft receptors is unprecedented. No work on dyslipidemia in patients undergoing liver transplantation to date has studied the relationship between the number of hours of sleep and this condition.2-4, 6 There are studies in the literature relating a higher number of hours of sleep per night and higher total cholesterol levels, but both increased (> 8 hours/day) and decreased (< 7 hours/day) sleep duration represent an increased risk of cardiovascular disease, diabetes and emergence of symptoms related to these conditions.44 The primary explanation to the deleterious effects of a greater number of hours of sleep is related to the fact that people who sleep more have lower levels of daily physical activity and consequently reduced energy expenditure.45 The indication for transplantation due to ethanolic cirrhosis was also a predictor of increased total cholesterol. Although cirrhotic patients must permanently abs-

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Prevalence and factors associated with dyslipidemia after liver transplantation

tain from alcohol to go on the transplant waiting list, it is likely that the former drinker will keep their old habits, generally associated with the intake of alcohol, as well as higher intake of fatty meats. A high intake of protein, total fats, saturated fats and cholesterol by light drinkers compared to nondrinkers has already been described in the literature.46 In this study, former drinkers had a significantly increased intake of calories, protein, total lipids, cholesterol and iron in relation to other patients with other indications for liver transplantation (p <0.05, Mann-Whitney U test, data not presented). Despite several studies citing immunosuppressive medication as a strong predictor for the presence of dyslipidemia,9-10 in this study, no association between the use of tacrolimus, cyclosporine or prednisone remained in the final models of the multivariate analysis. However, it is important to note that few patients at the time of assessment (11%, n=15) used cyclosporine as an immunosuppressive drug, which may represent a bias.

Conclusion The results of this study suggest that the majority of patients present some type of dyslipidemia afte r transplantation, with the most common types being reduced HDL, followed by hypertriglyceridemia. The predictive factors for the dyslipidemias studied include the existence of at least one potentially modifiable variable related to body composition, food intake or indications of the levels of physical activity. We should remain attentive to the need to institute measures for preventing the development of dyslipidemia after liver transplantation, decreasing cardiovascular risk, and thereby prolonging the survival of these individuals. Resumo Prevalência e fatores associados às dislipidemias pós-transplante hepático. Objetivo: determinar a prevalência de anormalidades de colesterol total (CT), lipoproteína de baixa densidade (LDL) e alta densidade (HDL) e triglicérides, e identificar fatores preditivos dessas desordens em pacientes submetidos ao transplante hepático (TxH). Métodos: estudo transversal de avaliação da prevalência de dislipidemias em pacientes submetidos ao TxH. Variáveis demográficas, socioeconômicas, clínicas, antropométricas e dietéticas foram coletadas para identificar os fatores associados utilizando análises estatísticas uni e multivariadas.

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Resultados: foram avaliados 136 pacientes, dos quais 68,1% apresentaram pelo menos um tipo de dislipidemia. O nível de triglicérides esteve elevado em 32,4% dos casos, a HDL reduzida em 49,3% dos pacientes e os níveis de LDL elevados em apenas 8,8%. Colesterol total elevado foi observado em 16,2% da população estudada e esteve associado à indicação de transplante por cirrose etanólica (OR = 2,7) e maior número de horas dormidas por noite (OR = 1,5). Conclusão: grande parte dos pacientes apresentou dislipidemia após o transplante, demonstrando a necessidade de intervenções em relação aos fatores modificáveis associados às dislipidemias que podem atenuar ou prevenir essas desordens. Unitermos: dislipidemia; lipoproteínas; prevalência; transplante de fígado.

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Prevalence and factors associated with

Original article Prevalence and factors associated with dyslipidemia after liver transplantation Prevalence and factors associated with dyslipidemia...

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